Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.
Journal Article (Journal Article)
Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.
Full Text
Duke Authors
Cited Authors
- Chung, SM; Proia, AD; Klintworth, GK; Watson, SP; Lapetina, EG
Published Date
- June 14, 1985
Published In
Volume / Issue
- 129 / 2
Start / End Page
- 411 - 416
PubMed ID
- 2990455
International Standard Serial Number (ISSN)
- 0006-291X
Digital Object Identifier (DOI)
- 10.1016/0006-291x(85)90166-4
Language
- eng
Conference Location
- United States