Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.
Publication
, Journal Article
Chung, SM; Proia, AD; Klintworth, GK; Watson, SP; Lapetina, EG
Published in: Biochem Biophys Res Commun
June 14, 1985
Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.
Duke Scholars
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
June 14, 1985
Volume
129
Issue
2
Start / End Page
411 / 416
Location
United States
Related Subject Headings
- Type C Phospholipases
- Rats
- Phospholipases
- Phosphatidylinositols
- Phosphatidylinositol Phosphates
- Male
- Kinetics
- In Vitro Techniques
- Hydrolysis
- Humans
Citation
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MLA
NLM
Chung, S. M., Proia, A. D., Klintworth, G. K., Watson, S. P., & Lapetina, E. G. (1985). Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C. Biochem Biophys Res Commun, 129(2), 411–416. https://doi.org/10.1016/0006-291x(85)90166-4
Chung, S. M., A. D. Proia, G. K. Klintworth, S. P. Watson, and E. G. Lapetina. “Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.” Biochem Biophys Res Commun 129, no. 2 (June 14, 1985): 411–16. https://doi.org/10.1016/0006-291x(85)90166-4.
Chung SM, Proia AD, Klintworth GK, Watson SP, Lapetina EG. Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C. Biochem Biophys Res Commun. 1985 Jun 14;129(2):411–6.
Chung, S. M., et al. “Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.” Biochem Biophys Res Commun, vol. 129, no. 2, June 1985, pp. 411–16. Pubmed, doi:10.1016/0006-291x(85)90166-4.
Chung SM, Proia AD, Klintworth GK, Watson SP, Lapetina EG. Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C. Biochem Biophys Res Commun. 1985 Jun 14;129(2):411–416.
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
June 14, 1985
Volume
129
Issue
2
Start / End Page
411 / 416
Location
United States
Related Subject Headings
- Type C Phospholipases
- Rats
- Phospholipases
- Phosphatidylinositols
- Phosphatidylinositol Phosphates
- Male
- Kinetics
- In Vitro Techniques
- Hydrolysis
- Humans