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Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.

Publication ,  Journal Article
Chung, SM; Proia, AD; Klintworth, GK; Watson, SP; Lapetina, EG
Published in: Biochem Biophys Res Commun
June 14, 1985

Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

June 14, 1985

Volume

129

Issue

2

Start / End Page

411 / 416

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • Rats
  • Phospholipases
  • Phosphatidylinositols
  • Phosphatidylinositol Phosphates
  • Male
  • Kinetics
  • In Vitro Techniques
  • Hydrolysis
  • Humans
 

Citation

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Chung, S. M., Proia, A. D., Klintworth, G. K., Watson, S. P., & Lapetina, E. G. (1985). Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C. Biochem Biophys Res Commun, 129(2), 411–416. https://doi.org/10.1016/0006-291x(85)90166-4
Chung, S. M., A. D. Proia, G. K. Klintworth, S. P. Watson, and E. G. Lapetina. “Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.Biochem Biophys Res Commun 129, no. 2 (June 14, 1985): 411–16. https://doi.org/10.1016/0006-291x(85)90166-4.
Chung SM, Proia AD, Klintworth GK, Watson SP, Lapetina EG. Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C. Biochem Biophys Res Commun. 1985 Jun 14;129(2):411–6.
Chung, S. M., et al. “Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.Biochem Biophys Res Commun, vol. 129, no. 2, June 1985, pp. 411–16. Pubmed, doi:10.1016/0006-291x(85)90166-4.
Chung SM, Proia AD, Klintworth GK, Watson SP, Lapetina EG. Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C. Biochem Biophys Res Commun. 1985 Jun 14;129(2):411–416.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

June 14, 1985

Volume

129

Issue

2

Start / End Page

411 / 416

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • Rats
  • Phospholipases
  • Phosphatidylinositols
  • Phosphatidylinositol Phosphates
  • Male
  • Kinetics
  • In Vitro Techniques
  • Hydrolysis
  • Humans