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Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation.

Publication ,  Journal Article
Cheng, R-K; Williams, CL; Meck, WH
Published in: Brain research
October 2008

Choline supplementation of the maternal diet has long-term facilitative effects on spatial and temporal memory processes in the offspring. To further delineate the impact of early nutritional status on brain and behavior, we examined effects of prenatal-choline availability on hippocampal oscillatory frequency bands in 12 month-old male and female rats. Adult offspring of time-pregnant dams that were given a deficient level of choline (DEF=0.0 g/kg), sufficient choline (CON=1.1 g/kg) or supplemental choline (SUP=3.5 g/kg) in their chow during embryonic days (ED) 12-17 were implanted with an electroencephalograph (EEG) electrode in the hippocampal dentate gyrus in combination with an electromyograph (EMG) electrode patch implanted in the nuchal muscle. Five consecutive 8-h recording sessions revealed differential patterns of EEG activity as a function of awake, slow-wave sleep (SWS) and rapid-eye movement (REM) sleep states and prenatal choline status. The main finding was that SUP rats displayed increased power levels of gamma (30-100 Hz) band oscillations during all phases of the sleep/wake cycle. These findings are discussed within the context of a general review of neuronal oscillations (e.g., delta, theta, and gamma bands) and synchronization across multiple brain regions in relation to sleep-dependent memory consolidation in the hippocampus.

Duke Scholars

Published In

Brain research

DOI

EISSN

1872-6240

ISSN

0006-8993

Publication Date

October 2008

Volume

1237

Start / End Page

176 / 194

Related Subject Headings

  • Time Factors
  • Sleep
  • Rats
  • Prenatal Nutritional Physiological Phenomena
  • Pregnancy
  • Nootropic Agents
  • Neurology & Neurosurgery
  • Memory
  • Male
  • Hippocampus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cheng, R.-K., Williams, C. L., & Meck, W. H. (2008). Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation. Brain Research, 1237, 176–194. https://doi.org/10.1016/j.brainres.2008.08.077
Cheng, Ruey-Kuang, Christina L. Williams, and Warren H. Meck. “Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation.Brain Research 1237 (October 2008): 176–94. https://doi.org/10.1016/j.brainres.2008.08.077.
Cheng, Ruey-Kuang, et al. “Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation.Brain Research, vol. 1237, Oct. 2008, pp. 176–94. Epmc, doi:10.1016/j.brainres.2008.08.077.
Journal cover image

Published In

Brain research

DOI

EISSN

1872-6240

ISSN

0006-8993

Publication Date

October 2008

Volume

1237

Start / End Page

176 / 194

Related Subject Headings

  • Time Factors
  • Sleep
  • Rats
  • Prenatal Nutritional Physiological Phenomena
  • Pregnancy
  • Nootropic Agents
  • Neurology & Neurosurgery
  • Memory
  • Male
  • Hippocampus