Adjuvant arthritis in T lymphocyte depleted rats.


Journal Article

Markedly T lymphocyte depleted rats were prepared by thymectomy, irradiation, and repopulation by bone marrow hematopoietic and lymphoid cells. Such rats had persistent T lymphopenia of about 20% of normal. When T depleted and normal rats were injected with adjuvant, all animals developed arthritis but with slightly less severity in the T depleted animals. Such experiments, and other observations, suggest a complex immunological mechanism in the pathogenesis of adjuvant arthritis in the rat.

Full Text

Cited Authors

  • Hollingsworth, JW; Greenberg, DS; Dawson, M

Published Date

  • June 1, 1976

Published In

Volume / Issue

  • 152 / 2

Start / End Page

  • 183 - 185

PubMed ID

  • 1084529

Pubmed Central ID

  • 1084529

Electronic International Standard Serial Number (EISSN)

  • 1525-1373

International Standard Serial Number (ISSN)

  • 0037-9727

Digital Object Identifier (DOI)

  • 10.3181/00379727-152-39356


  • eng