A new cardiac MASTer switch for the renin-angiotensin system.
Journal Article (Journal Article)
The aspartyl protease renin was first isolated from the kidney by Tigerstedt more than a century ago. In the kidney, renin secretion is tightly linked to sodium intake and renal perfusion pressure, reflecting the important role of the renin-angiotensin system (RAS) in controlling body fluid volume and blood pressure. The study by Mackins et al. in this issue of the JCI describes a novel source of renin: the mast cell (see the related article beginning on page 1063). This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact on the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart.
Full Text
Duke Authors
Cited Authors
- Le, TH; Coffman, TM
Published Date
- April 2006
Published In
Volume / Issue
- 116 / 4
Start / End Page
- 866 - 869
PubMed ID
- 16585956
Pubmed Central ID
- PMC1421370
International Standard Serial Number (ISSN)
- 0021-9738
Digital Object Identifier (DOI)
- 10.1172/JCI28312
Language
- eng
Conference Location
- United States