A new cardiac MASTer switch for the renin-angiotensin system.

Journal Article (Journal Article)

The aspartyl protease renin was first isolated from the kidney by Tigerstedt more than a century ago. In the kidney, renin secretion is tightly linked to sodium intake and renal perfusion pressure, reflecting the important role of the renin-angiotensin system (RAS) in controlling body fluid volume and blood pressure. The study by Mackins et al. in this issue of the JCI describes a novel source of renin: the mast cell (see the related article beginning on page 1063). This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact on the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart.

Full Text

Duke Authors

Cited Authors

  • Le, TH; Coffman, TM

Published Date

  • April 2006

Published In

Volume / Issue

  • 116 / 4

Start / End Page

  • 866 - 869

PubMed ID

  • 16585956

Pubmed Central ID

  • PMC1421370

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI28312


  • eng

Conference Location

  • United States