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Genetic profiling and tailored therapy in asthma: are we there yet?

Publication ,  Journal Article
Lugogo, NL; Ginsburg, GS; Que, LG
Published in: Curr Opin Mol Ther
December 2007

Asthma is characterized by reversible bronchial hyper-responsiveness and airway inflammation, and encompasses a wide variety of patients with different clinical phenotypes that display variable responses to therapy. The definition of genomic variation presented in the Human Genome Project has facilitated the development of genetic-guided therapy in various diseases, including asthma. Tailored therapy is a reality in many types of malignancies where specific gene mutations or molecular profiles are identified and used to make critical therapeutic decisions. Despite the identification of beta-adrenergic receptor polymorphisms by Liggett and colleagues during the 1990s, the pharmacogenetics of asthma is still in its infancy. There have been great advances in asthma pharmacogenetics and pharmacotherapy with the completion of several large trials highlighting the effects of genotype on response to asthma therapy. This review focuses on research articles that serve to emphasize the potential role of using genotyping as a tool to develop individualized patient treatment regimens for asthma, thus improving outcomes and limiting adverse effects of certain therapies.

Duke Scholars

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

December 2007

Volume

9

Issue

6

Start / End Page

528 / 537

Location

England

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Polymorphism, Genetic
  • Pharmacogenetics
  • Humans
  • Genotype
  • Genome, Human
  • Gene Expression Profiling
  • Biotechnology
  • Asthma
  • 3206 Medical biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lugogo, N. L., Ginsburg, G. S., & Que, L. G. (2007). Genetic profiling and tailored therapy in asthma: are we there yet? Curr Opin Mol Ther, 9(6), 528–537.
Lugogo, Njira L., Geoffrey S. Ginsburg, and Loretta G. Que. “Genetic profiling and tailored therapy in asthma: are we there yet?Curr Opin Mol Ther 9, no. 6 (December 2007): 528–37.
Lugogo NL, Ginsburg GS, Que LG. Genetic profiling and tailored therapy in asthma: are we there yet? Curr Opin Mol Ther. 2007 Dec;9(6):528–37.
Lugogo, Njira L., et al. “Genetic profiling and tailored therapy in asthma: are we there yet?Curr Opin Mol Ther, vol. 9, no. 6, Dec. 2007, pp. 528–37.
Lugogo NL, Ginsburg GS, Que LG. Genetic profiling and tailored therapy in asthma: are we there yet? Curr Opin Mol Ther. 2007 Dec;9(6):528–537.

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

December 2007

Volume

9

Issue

6

Start / End Page

528 / 537

Location

England

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Polymorphism, Genetic
  • Pharmacogenetics
  • Humans
  • Genotype
  • Genome, Human
  • Gene Expression Profiling
  • Biotechnology
  • Asthma
  • 3206 Medical biotechnology