Overall diet quality and age-related macular degeneration.
Journal Article (Journal Article)
PURPOSE: To examine overall diet quality in relation to advanced age-related macular degeneration (AMD). METHODS: This case-control study identified 437 advanced AMD patients and 259 unrelated controls using stereoscopic color fundus photographs. Participants were predominantly non-Hispanic White men and women from North Carolina and Tennessee. A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI). RESULTS: Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30-0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41-1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26-0.90). CONCLUSIONS: We found that advanced AMD was significantly related to overall diet quality. The AHEI score may be a useful instrument for assessing AMD risk due to diet, and it could potentially be improved by incorporating more specific information regarding micronutrient intake.
Full Text
Duke Authors
Cited Authors
- Montgomery, MP; Kamel, F; Pericak-Vance, MA; Haines, JL; Postel, EA; Agarwal, A; Richards, M; Scott, WK; Schmidt, S
Published Date
- January 2010
Published In
Volume / Issue
- 17 / 1
Start / End Page
- 58 - 65
PubMed ID
- 20100101
Pubmed Central ID
- PMC3685322
Electronic International Standard Serial Number (EISSN)
- 1744-5086
Digital Object Identifier (DOI)
- 10.3109/09286580903450353
Language
- eng
Conference Location
- England