Overall diet quality and age-related macular degeneration.

Journal Article (Journal Article)

PURPOSE: To examine overall diet quality in relation to advanced age-related macular degeneration (AMD). METHODS: This case-control study identified 437 advanced AMD patients and 259 unrelated controls using stereoscopic color fundus photographs. Participants were predominantly non-Hispanic White men and women from North Carolina and Tennessee. A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI). RESULTS: Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30-0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41-1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26-0.90). CONCLUSIONS: We found that advanced AMD was significantly related to overall diet quality. The AHEI score may be a useful instrument for assessing AMD risk due to diet, and it could potentially be improved by incorporating more specific information regarding micronutrient intake.

Full Text

Duke Authors

Cited Authors

  • Montgomery, MP; Kamel, F; Pericak-Vance, MA; Haines, JL; Postel, EA; Agarwal, A; Richards, M; Scott, WK; Schmidt, S

Published Date

  • January 2010

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 58 - 65

PubMed ID

  • 20100101

Pubmed Central ID

  • PMC3685322

Electronic International Standard Serial Number (EISSN)

  • 1744-5086

Digital Object Identifier (DOI)

  • 10.3109/09286580903450353


  • eng

Conference Location

  • England