ASH evidence-based guidelines: should asymptomatic patients with antiphospholipid antibodies receive primary prophylaxis to prevent thrombosis?


Journal Article (Review)

A 35-year-old female presents with a prolonged activated partial thromboplastin time (aPTT) on routine testing, which is found to be due to a lupus anticoagulant. She has no medical issues, no personal or family history of thrombosis, no history of pregnancy loss, and no symptoms suggestive of an underlying rheumatologic disorder. She is a non-smoker and does not take oral contraceptives. You are asked to provide recommendations regarding the need for primary thromboprophylaxis. As you begin your literature search, you formulate the following clinical question: "In asymptomatic patients with antiphospholipid antibodies, does primary prophylaxis prevent thrombotic complications?"

Full Text

Duke Authors

Cited Authors

  • Metjian, A; Lim, W

Published Date

  • 2009

Published In

Start / End Page

  • 247 - 249

PubMed ID

  • 20008205

Pubmed Central ID

  • 20008205

Electronic International Standard Serial Number (EISSN)

  • 1520-4383

Digital Object Identifier (DOI)

  • 10.1182/asheducation-2009.1.247


  • eng

Conference Location

  • United States