Local delivery of heparin post-PTCA: a multicenter randomized pilot study.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

Bailout stenting for major dissection and threatened closure has high rates of ischemic complications. We performed a randomized trial of local heparin delivery using the infusion sleeve before bailout stenting for suboptimal angioplasty results. In phase I, 20 patients were randomized to local delivery with either 40- or 100-psi infusion pressure. In phase II, 37 patients were randomized to local delivery at 100 psi or standard therapy. Local delivery succeeded in all but one patient; overall there was no significant worsening of intimal dissection. One patient treated with 100-psi drug infusion suffered a perforation after stent placement. There were no significant differences in the composite endpoint of death, MI, CABG, urgent repeat angioplasty, and stent thrombosis at 30 days (21% vs. 0%; P = 0.18). At 6 months, the rates of myocardial infarction in phase II were 27% with local delivery vs. 10% with standard treatment (P = 0.4). Local heparin delivery in dissected vessels may be associated with increased complications and should be approached with caution.

Full Text

Duke Authors

Cited Authors

  • Tanguay, JF; Cantor, WJ; Krucoff, MW; Muhlestein, B; Barsness, GW; Zidar, JP; Sketch, MH; Tcheng, JE; Phillips, HR; Stack, RS; Kaplan, AV; Ohman, EM

Published Date

  • April 2000

Published In

Volume / Issue

  • 49 / 4

Start / End Page

  • 461 - 467

PubMed ID

  • 10751780

International Standard Serial Number (ISSN)

  • 1522-1946

Digital Object Identifier (DOI)

  • 10.1002/(sici)1522-726x(200004)49:4<461::aid-ccd26>3.0.co;2-7


  • eng

Conference Location

  • United States