The natural history of single-vessel chronic coronary occlusion: a 25-year experience.


Journal Article

To determine the natural history of patients with a total occlusion of a single coronary artery, we searched the Duke Databank for Cardiovascular Disease to find all patients who underwent a first coronary angiogram >2 days after a symptomatic myocardial infarction between 1969 and 1994. Patients who underwent angiography >30 days after the acute event had a low risk of death in the first year (3%), and a proximal left anterior descending coronary occlusion did not confer substantially higher risk of death (4%). Patients undergoing angiography <30 days after the acute event had a higher mortality (5%), especially those with proximal left anterior descending occlusion (10%). The time from the acute event to angiography was a predictor of death (p = 0.04). Despite low 1-year mortality rates, patients with total occlusion of an isolated coronary vessel treated medically had substantial mortality, myocardial infarction, and revascularization rates over a long-term follow-up period.

Full Text

Duke Authors

Cited Authors

  • Puma, JA; Sketch, MH; Tcheng, JE; Gardner, LH; Nelson, CL; Phillips, HR; Stack, RS; Califf, RM

Published Date

  • April 1997

Published In

Volume / Issue

  • 133 / 4

Start / End Page

  • 393 - 399

PubMed ID

  • 9124159

Pubmed Central ID

  • 9124159

International Standard Serial Number (ISSN)

  • 0002-8703

Digital Object Identifier (DOI)

  • 10.1016/s0002-8703(97)70179-0


  • eng

Conference Location

  • United States