Reduction in vascular access site bleeding in sequential abciximab coronary intervention trials.

Published

Journal Article

We analyzed vascular access site bleeding from the EPIC, EPILOG, and EPISTENT trials to quantify the decrease in vascular bleeding complications in these three trials, especially those attributable to abciximab. The incidence of combined major and minor vascular access site bleeding in nonabciximab (heparin plus placebo) patients progressively decreased from EPIC (8.2%) to EPILOG (2.9%) to EPISTENT (1.7%; P < 0.001). Combined major and minor vascular access site bleeding in abciximab (heparin plus abciximab) patients decreased from EPIC (20%) to EPILOG (5.8%) to EPISTENT (2.2%; P < 0.001). There were more major vascular access site bleeds with abciximab compared to placebo in EPIC (odds ration 3.2; P < 0.001) but not in EPILOG or EPISTENT. Modified abciximab and heparin dosing and improved vascular access site management strategies have decreased the risk of vascular access bleeding during coronary intervention and have essentially eliminated the excess access site bleeding associated with abciximab.

Full Text

Duke Authors

Cited Authors

  • Blankenship, JC; Balog, C; Sapp, SK; Califf, RM; Lincoff, AM; Tcheng, JE; Topol, EJ

Published Date

  • December 2002

Published In

Volume / Issue

  • 57 / 4

Start / End Page

  • 476 - 483

PubMed ID

  • 12455081

Pubmed Central ID

  • 12455081

Electronic International Standard Serial Number (EISSN)

  • 1522-726X

International Standard Serial Number (ISSN)

  • 1522-1946

Digital Object Identifier (DOI)

  • 10.1002/ccd.10322

Language

  • eng