Effects of the Dietary Approaches to Stop Hypertension (DASH) diet on the pressure-natriuresis relationship.


Journal Article

Blood pressure-lowering mechanisms of the Dietary Approaches to Stop Hypertension (DASH) diet, rich in fruits, vegetables, and low-fat dairy foods, were analyzed based on the pressure-natriuresis relationship. Participants (n=375) were randomly assigned to control or DASH diet groups by using a parallel-group design. They then ate their assigned diet for 3 consecutive 30-day intervention feeding periods, during which sodium intake varied among 3 levels by a randomly assigned sequence. Urinary sodium excretion rate and mean arterial pressure were measured at the end of each sodium intake level. Mean arterial pressure and urinary sodium excretion were plotted on x and y axes, respectively, for participants eating control and DASH diets and were modeled as linear relationships for simplicity to allow the estimation of the extrapolated x-intercept and slope of the relationships. The DASH diet steepened the slope of the relationship (29.5+/-3.4 vs 64.9+/-13.1 [mmol/d]/mm Hg, P=0.0002) without significantly shifting the x-intercept (94.1+/-0.5 vs 93.2+/-0.6 mm Hg, NS) of the relationship. These data suggest a natriuretic action of the DASH diet.

Full Text

Duke Authors

Cited Authors

  • Akita, S; Sacks, FM; Svetkey, LP; Conlin, PR; Kimura, G; DASH-Sodium Trial Collaborative Research Group,

Published Date

  • July 2003

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 8 - 13

PubMed ID

  • 12756219

Pubmed Central ID

  • 12756219

Electronic International Standard Serial Number (EISSN)

  • 1524-4563

Digital Object Identifier (DOI)

  • 10.1161/01.HYP.0000074668.08704.6E


  • eng

Conference Location

  • United States