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The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.

Publication ,  Journal Article
Haqq, AM; Lien, LF; Boan, J; Arlotto, M; Slentz, CA; Muehlbauer, MJ; Rochon, J; Gallup, D; McMahon, RL; Bain, JR; Stevens, R; Millington, D ...
Published in: Contemp Clin Trials
December 2005

This paper outlines the rationale and design of the Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project, in which detailed biologic profiling of three hundred and fifty obese individuals (body mass index (BMI): 30-50 kg/m(2)) will be conducted as they lose weight via seven distinct interventions. These profiles will be compared to those of fifty normal, healthy, control participants (BMI: 18.5-24.9 kg/m(2)). The interventions include the following: Roux-en-Y gastric bypass surgery, dietary interventions of differing macronutrient composition and diverse pharmacologic interventions. Outcome variables include eight conventional metabolites and CRP measured by standard clinical chemistry techniques, twenty hormones of energy balance and fuel homeostasis measured by radioimmunoassay (RIA) or by enzyme-linked Immunosorbent assay (ELISA), ten pro- and anti-inflammatory cytokines measured using Luminex xMAP technology, one hundred and one intermediary metabolites measured by targeted mass-spectrometry-based methods, and physiologic variables such as body composition measured by dual energy X-ray absorptiometry (DEXA), air displacement plethysmography, and abdominal computerized tomography (CT), insulin sensitivity measured by intravenous glucose tolerance test (IV-GTT) and metabolic rate measured by indirect calorimetry. Results from this study will expand our knowledge of the biology of obesity and weight regulation and may lead to targeted strategies for its treatment and control.

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Published In

Contemp Clin Trials

DOI

ISSN

1551-7144

Publication Date

December 2005

Volume

26

Issue

6

Start / End Page

616 / 625

Location

United States

Related Subject Headings

  • Weight Loss
  • Research Design
  • Public Health
  • Obesity
  • Middle Aged
  • Humans
  • General Clinical Medicine
  • Gastric Bypass
  • Clinical Trials as Topic
  • Body Weights and Measures
 

Citation

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Haqq, A. M., Lien, L. F., Boan, J., Arlotto, M., Slentz, C. A., Muehlbauer, M. J., … Svetkey, L. P. (2005). The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design. Contemp Clin Trials, 26(6), 616–625. https://doi.org/10.1016/j.cct.2005.09.003
Haqq, Andrea M., Lillian F. Lien, Jarol Boan, Michelle Arlotto, Cris A. Slentz, Michael J. Muehlbauer, James Rochon, et al. “The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.Contemp Clin Trials 26, no. 6 (December 2005): 616–25. https://doi.org/10.1016/j.cct.2005.09.003.
Haqq AM, Lien LF, Boan J, Arlotto M, Slentz CA, Muehlbauer MJ, et al. The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design. Contemp Clin Trials. 2005 Dec;26(6):616–25.
Haqq, Andrea M., et al. “The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.Contemp Clin Trials, vol. 26, no. 6, Dec. 2005, pp. 616–25. Pubmed, doi:10.1016/j.cct.2005.09.003.
Haqq AM, Lien LF, Boan J, Arlotto M, Slentz CA, Muehlbauer MJ, Rochon J, Gallup D, McMahon RL, Bain JR, Stevens R, Millington D, Butler MD, Newgard CB, Svetkey LP. The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design. Contemp Clin Trials. 2005 Dec;26(6):616–625.
Journal cover image

Published In

Contemp Clin Trials

DOI

ISSN

1551-7144

Publication Date

December 2005

Volume

26

Issue

6

Start / End Page

616 / 625

Location

United States

Related Subject Headings

  • Weight Loss
  • Research Design
  • Public Health
  • Obesity
  • Middle Aged
  • Humans
  • General Clinical Medicine
  • Gastric Bypass
  • Clinical Trials as Topic
  • Body Weights and Measures