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Comparing office-based and ambulatory blood pressure monitoring in clinical trials.

Publication ,  Journal Article
Vollmer, WM; Appel, LJ; Svetkey, LP; Moore, TJ; Vogt, TM; Conlin, PR; Proschan, M; Harsha, D; DASH Collaborative Research Group,
Published in: J Hum Hypertens
January 2005

Ambulatory blood pressure monitoring (ABPM) is commonly used in clinical trials. Yet, its ability to detect blood pressure (BP) change in comparison to multiple office-based measurements has received limited attention. We recorded ambulatory and five daily pairs of random zero (RZ) BPs pre- and post-intervention on 321 adult participants in the multicentre Dietary Approaches to Stop Hypertension trial. Treatment effect estimates measured by ambulatory monitoring were similar to those measured by RZ and did not differ significantly for waking vs 24-h ambulatory measurements. For systolic BP, the standard deviations of change in mean 24-h ambulatory BP (8.0 mmHg among hypertensives and 6.0 mmHg among nonhypertensives) were comparable to or lower than the corresponding standard deviations of change in RZ-BP based on five daily readings (8.9 and 5.9 mmHg). The standard deviations of change for mean waking ambulatory BP (8.7 and 6.7 mmHg) were comparable to those obtained using three to four daily RZ readings. Results for diastolic BP were qualitatively similar. Ambulatory monitoring was more efficient (ie, a smaller sample size could detect a given BP change) than three to four sets of daily RZ readings and required fewer clinic visits. The average of 33 ambulatory BP readings during the waking hours had an efficiency comparable to that from the mean of four daily pairs of RZ-BPs. Participants readily accepted the ABPM devices, and their use requires less staff training. ABPM provides a useful alternative to RZ-BP measurements in clinical trials.

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Published In

J Hum Hypertens

DOI

ISSN

0950-9240

Publication Date

January 2005

Volume

19

Issue

1

Start / End Page

77 / 82

Location

England

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Office Visits
  • Male
  • Hypertension
  • Humans
  • Female
  • Clinical Protocols
  • Circadian Rhythm
  • Cardiovascular System & Hematology
 

Citation

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Vollmer, W. M., Appel, L. J., Svetkey, L. P., Moore, T. J., Vogt, T. M., Conlin, P. R., … DASH Collaborative Research Group, . (2005). Comparing office-based and ambulatory blood pressure monitoring in clinical trials. J Hum Hypertens, 19(1), 77–82. https://doi.org/10.1038/sj.jhh.1001772
Vollmer, W. M., L. J. Appel, L. P. Svetkey, T. J. Moore, T. M. Vogt, P. R. Conlin, M. Proschan, D. Harsha, and D. DASH Collaborative Research Group. “Comparing office-based and ambulatory blood pressure monitoring in clinical trials.J Hum Hypertens 19, no. 1 (January 2005): 77–82. https://doi.org/10.1038/sj.jhh.1001772.
Vollmer WM, Appel LJ, Svetkey LP, Moore TJ, Vogt TM, Conlin PR, et al. Comparing office-based and ambulatory blood pressure monitoring in clinical trials. J Hum Hypertens. 2005 Jan;19(1):77–82.
Vollmer, W. M., et al. “Comparing office-based and ambulatory blood pressure monitoring in clinical trials.J Hum Hypertens, vol. 19, no. 1, Jan. 2005, pp. 77–82. Pubmed, doi:10.1038/sj.jhh.1001772.
Vollmer WM, Appel LJ, Svetkey LP, Moore TJ, Vogt TM, Conlin PR, Proschan M, Harsha D, DASH Collaborative Research Group. Comparing office-based and ambulatory blood pressure monitoring in clinical trials. J Hum Hypertens. 2005 Jan;19(1):77–82.

Published In

J Hum Hypertens

DOI

ISSN

0950-9240

Publication Date

January 2005

Volume

19

Issue

1

Start / End Page

77 / 82

Location

England

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Office Visits
  • Male
  • Hypertension
  • Humans
  • Female
  • Clinical Protocols
  • Circadian Rhythm
  • Cardiovascular System & Hematology