Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.


Journal Article

OBJECTIVE: It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor. METHODS: Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion polymorphism (Ins/Del): G12269A, C17888T, and G20037A. Time to reach target mean arterial pressure (

Full Text

Duke Authors

Cited Authors

  • Bhatnagar, V; O'Connor, DT; Schork, NJ; Salem, RM; Nievergelt, CM; Rana, BK; Smith, DW; Bakris, GL; Middleton, JP; Norris, KC; Wright, JT; Cheek, D; Hiremath, L; Contreras, G; Appel, LJ; Lipkowitz, MS

Published Date

  • October 2007

Published In

Volume / Issue

  • 25 / 10

Start / End Page

  • 2082 - 2092

PubMed ID

  • 17885551

Pubmed Central ID

  • 17885551

International Standard Serial Number (ISSN)

  • 0263-6352

Digital Object Identifier (DOI)

  • 10.1097/HJH.0b013e3282b9720e


  • eng

Conference Location

  • England