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Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.

Publication ,  Journal Article
Bhatnagar, V; O'Connor, DT; Schork, NJ; Salem, RM; Nievergelt, CM; Rana, BK; Smith, DW; Bakris, GL; Middleton, JP; Norris, KC; Wright, JT ...
Published in: J Hypertens
October 2007

OBJECTIVE: It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor. METHODS: Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion polymorphism (Ins/Del): G12269A, C17888T, and G20037A. Time to reach target mean arterial pressure (

Duke Scholars

Published In

J Hypertens

DOI

ISSN

0263-6352

Publication Date

October 2007

Volume

25

Issue

10

Start / End Page

2082 / 2092

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Renal Insufficiency
  • Ramipril
  • Polymorphism, Single Nucleotide
  • Peptidyl-Dipeptidase A
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Haplotypes
 

Citation

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Chicago
ICMJE
MLA
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Bhatnagar, V., O’Connor, D. T., Schork, N. J., Salem, R. M., Nievergelt, C. M., Rana, B. K., … Lipkowitz, M. S. (2007). Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens, 25(10), 2082–2092. https://doi.org/10.1097/HJH.0b013e3282b9720e
Bhatnagar, Vibha, Daniel T. O’Connor, Nicholas J. Schork, Rany M. Salem, Caroline M. Nievergelt, Brinda K. Rana, Douglas W. Smith, et al. “Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.J Hypertens 25, no. 10 (October 2007): 2082–92. https://doi.org/10.1097/HJH.0b013e3282b9720e.
Bhatnagar V, O’Connor DT, Schork NJ, Salem RM, Nievergelt CM, Rana BK, et al. Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct;25(10):2082–92.
Bhatnagar, Vibha, et al. “Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.J Hypertens, vol. 25, no. 10, Oct. 2007, pp. 2082–92. Pubmed, doi:10.1097/HJH.0b013e3282b9720e.
Bhatnagar V, O’Connor DT, Schork NJ, Salem RM, Nievergelt CM, Rana BK, Smith DW, Bakris GL, Middleton JP, Norris KC, Wright JT, Cheek D, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS. Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct;25(10):2082–2092.

Published In

J Hypertens

DOI

ISSN

0263-6352

Publication Date

October 2007

Volume

25

Issue

10

Start / End Page

2082 / 2092

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Renal Insufficiency
  • Ramipril
  • Polymorphism, Single Nucleotide
  • Peptidyl-Dipeptidase A
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Haplotypes