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Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients.

Publication ,  Journal Article
Li, Y; Friedman, JY; O'Neal, BF; Hohenboken, MJ; Griffiths, RI; Stryjewski, ME; Middleton, JP; Schulman, KA; Inrig, JK; Fowler, VG; Reed, SD
Published in: Clin J Am Soc Nephrol
February 2009

BACKGROUND AND OBJECTIVES: Staphylococcus aureus is a leading cause of infection in patients with ESRD. Clinical and economic outcomes associated with S. aureus bacteremia and other S. aureus infections in patients with ESRD were examined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Laboratory, clinical, and hospital billing data from a randomized trial of 3359 hemodialysis-dependent patients hospitalized with S. aureus infection in the United States whose vascular access type was fistula or graft and who were hospitalized with S. aureus infection to evaluate inpatient costs, hospital days, and mortality over 12 wk were used. Generalized linear regression was used to identify independent predictors of 12-wk costs, inpatient days, and mortality. RESULTS: Of the 279 patients (8.3%) who developed S. aureus infection during approximately 1 yr of follow-up, 25.4% were treated as outpatients. Among patients for whom billing data were available, 89 patients hospitalized with S. aureus bacteremia incurred mean 12-wk inpatient costs of $19,454 and 11.9 inpatient days. Among the 70 patients hospitalized with non-bloodstream S. aureus infections, mean inpatient costs were $19,222 and the mean number of inpatient days was 11.3. Twelve-week mortality was 20.2 and 15.7% for patients with S. aureus bloodstream and non-bloodstream infections, respectively. Older age was independently associated with higher risk of death among patients with S. aureus bacteremia and with higher inpatient costs and more hospital days among patients with non-bloodstream infections. CONCLUSIONS: Hemodialysis-dependent patients with fistula or graft access incur high costs and long inpatient stays when hospitalized for S. aureus infection.

Duke Scholars

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

February 2009

Volume

4

Issue

2

Start / End Page

428 / 434

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • United States
  • Treatment Outcome
  • Time Factors
  • Staphylococcus aureus
  • Staphylococcal Vaccines
  • Staphylococcal Infections
  • Risk Factors
  • Risk Assessment
  • Renal Dialysis
 

Citation

APA
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MLA
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Li, Y., Friedman, J. Y., O’Neal, B. F., Hohenboken, M. J., Griffiths, R. I., Stryjewski, M. E., … Reed, S. D. (2009). Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients. Clin J Am Soc Nephrol, 4(2), 428–434. https://doi.org/10.2215/CJN.03760708
Li, Yanhong, Joëlle Y. Friedman, Betsy F. O’Neal, Matthew J. Hohenboken, Robert I. Griffiths, Martin E. Stryjewski, John P. Middleton, et al. “Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients.Clin J Am Soc Nephrol 4, no. 2 (February 2009): 428–34. https://doi.org/10.2215/CJN.03760708.
Li Y, Friedman JY, O’Neal BF, Hohenboken MJ, Griffiths RI, Stryjewski ME, et al. Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients. Clin J Am Soc Nephrol. 2009 Feb;4(2):428–34.
Li, Yanhong, et al. “Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients.Clin J Am Soc Nephrol, vol. 4, no. 2, Feb. 2009, pp. 428–34. Pubmed, doi:10.2215/CJN.03760708.
Li Y, Friedman JY, O’Neal BF, Hohenboken MJ, Griffiths RI, Stryjewski ME, Middleton JP, Schulman KA, Inrig JK, Fowler VG, Reed SD. Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients. Clin J Am Soc Nephrol. 2009 Feb;4(2):428–434.

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

February 2009

Volume

4

Issue

2

Start / End Page

428 / 434

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • United States
  • Treatment Outcome
  • Time Factors
  • Staphylococcus aureus
  • Staphylococcal Vaccines
  • Staphylococcal Infections
  • Risk Factors
  • Risk Assessment
  • Renal Dialysis