Neuropsychological effects and attitudes in patients following electroconvulsive therapy.


Journal Article

The current study examined the effects of electroconvulsive therapy (ECT) on neuropsychological test performance. Forty-six patients completed brief neuropsychological and psychological testing before and after receiving ECT for the treatment of recalcitrant and severe depression. Neuropsychological testing consisted of the Levin Selective Reminding Test (Levin) and Wechsler Memory Scale-Revised Edition (WMS-R). Self-report measures included the Beck Depression Inventory (BDI), the Short-Term Memory Questionnaire (STMQ), and several other measures of emotional functioning and patient attitudes toward ECT. The mean number of days between pre-ECT and post-ECT testing was 24. T-test revealed a significant decrease in subjective ratings of depression as rated by the BDI, t(45) = 9.82, P < 0.0001 (Pre-BDI = 27.9 +/- 20.2; post-BDI = 13.5 +/- 9.7). Objective ratings of memory appeared impaired following treatment, and patients' self-report measures of memory confirmed this decline. More specifically, repeated measures MANOVA [Wilks Lambda F(11,30) = 4.3, p < 0.001] indicated significant decreases for measures of immediate recognition memory (p < 0.005), long-term storage (p < 0.05), delayed prose passage recall (p < 0.0001), percent retained of prose passages (p < 0.0001), and percent retained of visual designs (p < 0.0001). In addition, the number of double mentions on the Levin increased (p < 0.02). This study suggests that there may be a greater need to discuss the intermittent cognitive risks associated with ECT when obtaining informed consent prior to treatment. Further that self-reports of cognitive difficulties may persist even when depression has remitted. However, patients may not acknowledge or be aware of changes in their memory functioning, and post-ECT self-reports may not be reliable.

Full Text

Duke Authors

Cited Authors

  • Feliu, M; Edwards, CL; Sudhakar, S; McDougald, C; Raynor, R; Johnson, S; Byrd, G; Whitfield, K; Jonassaint, C; Romero, H; Edwards, L; Wellington, C; Hill, LK; Sollers, J; Logue, PE

Published Date

  • June 2008

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 613 - 617

PubMed ID

  • 18830401

Pubmed Central ID

  • 18830401

International Standard Serial Number (ISSN)

  • 1176-6328

Digital Object Identifier (DOI)

  • 10.2147/ndt.s2037


  • eng

Conference Location

  • New Zealand