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Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.

Publication ,  Journal Article
Rubatt, JM; Darcy, KM; Hutson, A; Bean, SM; Havrilesky, LJ; Grace, LA; Berchuck, A; Secord, AA
Published in: Gynecol Oncol
March 2009

OBJECTIVES: The aims of this study were to examine prognostic significance of microvessel density (MVD) in previously-untreated, advanced epithelial ovarian cancer (EOC) and explore associations between MVD and factors that affect angiogenesis. METHODS: MVD was determined by immunohistochemical expression of CD31 or CD105 in tumor sections from 106 women treated on GOG randomized phase III trials. Average MVD hotspots were quantified by light microscopy at high power (x400) and categorized as low (

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Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

March 2009

Volume

112

Issue

3

Start / End Page

469 / 474

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factor A
  • Thrombospondin 1
  • Serpins
  • Receptors, Cell Surface
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Middle Aged
 

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Rubatt, J. M., Darcy, K. M., Hutson, A., Bean, S. M., Havrilesky, L. J., Grace, L. A., … Secord, A. A. (2009). Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. Gynecol Oncol, 112(3), 469–474. https://doi.org/10.1016/j.ygyno.2008.11.030
Rubatt, Jennifer M., Kathleen M. Darcy, Alan Hutson, Sarah M. Bean, Laura J. Havrilesky, Lisa A. Grace, Andrew Berchuck, and Angeles Alvarez Secord. “Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.Gynecol Oncol 112, no. 3 (March 2009): 469–74. https://doi.org/10.1016/j.ygyno.2008.11.030.
Journal cover image

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

March 2009

Volume

112

Issue

3

Start / End Page

469 / 474

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factor A
  • Thrombospondin 1
  • Serpins
  • Receptors, Cell Surface
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Middle Aged