Exploring type I angiotensin (AT1) receptor functions through gene targeting.

Journal Article (Journal Article;Review)

The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT(1)) class of angiotensin receptors. Pharmacological blockade of the AT(1) receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene-targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene-targeting experiments have elucidated AT(1) receptor functions.

Full Text

Duke Authors

Cited Authors

  • Crowley, SD; Tharaux, P-L; Audoly, LP; Coffman, TM

Published Date

  • August 2004

Published In

Volume / Issue

  • 181 / 4

Start / End Page

  • 561 - 570

PubMed ID

  • 15283771

International Standard Serial Number (ISSN)

  • 0001-6772

Digital Object Identifier (DOI)

  • 10.1111/j.1365-201X.2004.01331.x


  • eng

Conference Location

  • England