Exploring type I angiotensin (AT1) receptor functions through gene targeting.
Published
Journal Article (Review)
The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT(1)) class of angiotensin receptors. Pharmacological blockade of the AT(1) receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene-targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene-targeting experiments have elucidated AT(1) receptor functions.
Full Text
Duke Authors
Cited Authors
- Crowley, SD; Tharaux, P-L; Audoly, LP; Coffman, TM
Published Date
- August 2004
Published In
Volume / Issue
- 181 / 4
Start / End Page
- 561 - 570
PubMed ID
- 15283771
Pubmed Central ID
- 15283771
International Standard Serial Number (ISSN)
- 0001-6772
Digital Object Identifier (DOI)
- 10.1111/j.1365-201X.2004.01331.x
Language
- eng
Conference Location
- England