Mouse models of diabetic nephropathy.


Journal Article (Review)

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to validate a complete murine model of human diabetic kidney disease. Nonetheless, the critical analysis of existing murine models substantially enhances our understanding of this disease process.

Full Text

Duke Authors

Cited Authors

  • Brosius, FC; Alpers, CE; Bottinger, EP; Breyer, MD; Coffman, TM; Gurley, SB; Harris, RC; Kakoki, M; Kretzler, M; Leiter, EH; Levi, M; McIndoe, RA; Sharma, K; Smithies, O; Susztak, K; Takahashi, N; Takahashi, T; Animal Models of Diabetic Complications Consortium,

Published Date

  • December 2009

Published In

Volume / Issue

  • 20 / 12

Start / End Page

  • 2503 - 2512

PubMed ID

  • 19729434

Pubmed Central ID

  • 19729434

Electronic International Standard Serial Number (EISSN)

  • 1533-3450

Digital Object Identifier (DOI)

  • 10.1681/ASN.2009070721


  • eng

Conference Location

  • United States