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High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent.

Publication ,  Journal Article
Howles, GP; Ghaghada, KB; Qi, Y; Mukundan, S; Johnson, GA
Published in: Magn Reson Med
December 2009

High-resolution magnetic resonance angiography is already a useful tool for studying mouse models of human disease. Magnetic resonance angiography in the mouse is typically performed using time-of-flight contrast. In this work, a new long-circulating blood-pool contrast agent-a liposomal nanoparticle with surface-conjugated gadolinium (SC-Gd liposomes)-was evaluated for use in mouse neurovascular magnetic resonance angiography. A total of 12 mice were imaged. Scan parameters were optimized for both time-of-flight and SC-Gd contrast. Compared to time-of-flight contrast, SC-Gd liposomes (0.08 mmol/kg) enabled improved small-vessel contrast-to-noise ratio, larger field of view, shorter scan time, and imaging of venous structures. For a limited field of view, time-of-flight and SC-Gd were not significantly different; however, SC-Gd provided better contrast-to-noise ratio when the field of view encompassed the whole brain (P < 0.001) or the whole neurovascular axis (P < 0.001). SC-Gd allowed acquisition of high-resolution magnetic resonance angiography (52 x 52 x 100 micrometer(3) or 0.27 nL), with 123% higher (P < 0.001) contrast-to-noise ratio in comparable scan time ( approximately 45 min). Alternatively, SC-Gd liposomes could be used to acquire high-resolution magnetic resonance angiography (0.27 nL) with 32% higher contrast-to-noise ratio (P < 0.001) in 75% shorter scan time (12 min).

Duke Scholars

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

December 2009

Volume

62

Issue

6

Start / End Page

1447 / 1456

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Nanoparticles
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Magnetic Resonance Angiography
  • Liposomes
  • Image Enhancement
  • Gadolinium
  • Contrast Media
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Howles, G. P., Ghaghada, K. B., Qi, Y., Mukundan, S., & Johnson, G. A. (2009). High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent. Magn Reson Med, 62(6), 1447–1456. https://doi.org/10.1002/mrm.22154
Howles, Gabriel P., Ketan B. Ghaghada, Yi Qi, Srinivasan Mukundan, and G Allan Johnson. “High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent.Magn Reson Med 62, no. 6 (December 2009): 1447–56. https://doi.org/10.1002/mrm.22154.
Howles GP, Ghaghada KB, Qi Y, Mukundan S, Johnson GA. High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent. Magn Reson Med. 2009 Dec;62(6):1447–56.
Howles, Gabriel P., et al. “High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent.Magn Reson Med, vol. 62, no. 6, Dec. 2009, pp. 1447–56. Pubmed, doi:10.1002/mrm.22154.
Howles GP, Ghaghada KB, Qi Y, Mukundan S, Johnson GA. High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent. Magn Reson Med. 2009 Dec;62(6):1447–1456.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

December 2009

Volume

62

Issue

6

Start / End Page

1447 / 1456

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Nanoparticles
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Magnetic Resonance Angiography
  • Liposomes
  • Image Enhancement
  • Gadolinium
  • Contrast Media