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Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.

Publication ,  Journal Article
Bucholz, E; Ghaghada, K; Qi, Y; Mukundan, S; Rockman, HA; Johnson, GA
Published in: Magn Reson Med
April 2010

MR microscopy has enormous potential for small-animal cardiac imaging because it is capable of producing volumetric images at multiple time points to accurately measure cardiac function. MR has not been used as frequently as ultrasound to measure cardiac function in the small animal because the MR methods required relatively long scan times, limiting throughput. Here, we demonstrate four-dimensional radial acquisition in conjunction with a liposomal blood pool agent to explore functional differences in three populations of mice: six C57BL/6J mice, six DBA/2J mice, and six DBA/2J CSQ+ mice, all with the same gestational age and approximately the same weight. Cardiovascular function was determined by measuring both left ventricular and right ventricular end diastolic volume, end systolic volume, stroke volume, and ejection fraction. Statistical significance was observed in end diastolic volume, end systolic volume, and ejection fraction for left ventricular measurements between all three populations of mice. No statistically significant difference was observed in stroke volume in either the left or right ventricle for any of the three populations of mice. This study shows that MRI is capable of efficient, high-throughput, four-dimensional cardiovascular phenotyping of the mouse.

Duke Scholars

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

April 2010

Volume

63

Issue

4

Start / End Page

979 / 987

Location

United States

Related Subject Headings

  • Phenotype
  • Nuclear Medicine & Medical Imaging
  • Mice, Inbred DBA
  • Mice, Inbred C57BL
  • Mice
  • Magnetic Resonance Imaging
  • Liposomes
  • Imaging, Three-Dimensional
  • Gadolinium DTPA
  • Contrast Media
 

Citation

APA
Chicago
ICMJE
MLA
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Bucholz, E., Ghaghada, K., Qi, Y., Mukundan, S., Rockman, H. A., & Johnson, G. A. (2010). Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA. Magn Reson Med, 63(4), 979–987. https://doi.org/10.1002/mrm.22259
Bucholz, Elizabeth, Ketan Ghaghada, Yi Qi, Srinivasan Mukundan, Howard A. Rockman, and G Allan Johnson. “Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.Magn Reson Med 63, no. 4 (April 2010): 979–87. https://doi.org/10.1002/mrm.22259.
Bucholz E, Ghaghada K, Qi Y, Mukundan S, Rockman HA, Johnson GA. Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA. Magn Reson Med. 2010 Apr;63(4):979–87.
Bucholz, Elizabeth, et al. “Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.Magn Reson Med, vol. 63, no. 4, Apr. 2010, pp. 979–87. Pubmed, doi:10.1002/mrm.22259.
Bucholz E, Ghaghada K, Qi Y, Mukundan S, Rockman HA, Johnson GA. Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA. Magn Reson Med. 2010 Apr;63(4):979–987.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

April 2010

Volume

63

Issue

4

Start / End Page

979 / 987

Location

United States

Related Subject Headings

  • Phenotype
  • Nuclear Medicine & Medical Imaging
  • Mice, Inbred DBA
  • Mice, Inbred C57BL
  • Mice
  • Magnetic Resonance Imaging
  • Liposomes
  • Imaging, Three-Dimensional
  • Gadolinium DTPA
  • Contrast Media