Motor neuron disease and serum monoclonal proteins: poor response to treatment of the paraproteinemia.

Journal Article (Journal Article)

An association between motor neuron disease (MND) and paraproteinemia has been previously reported. In a retrospective study, we found that 13 of 117 (11%) patients with MND who had serum protein electrophoresis studies were found to have a serum M-protem. Eleven of 13 patients had probable or definite amyotrophic lateral sclerosis (ALS), Of the 11 patients with ALS, six were treated with immunotherapy or chemotherapy. Subjective or objective neurologic improvement was not identified in any. Our data support an association between MND and paraproteinemia, but response to treatment of the paraproteinemia was disappointing. Searching for an M-protein in probable or definite ALS may not be therapeutically relevant.

Full Text

Duke Authors

Cited Authors

  • Burns, MT; Juel, VC; Hess, CE; Phillips, LH

Published Date

  • December 2000

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • 70 - 72

PubMed ID

  • 19078608

Electronic International Standard Serial Number (EISSN)

  • 1537-1611

Digital Object Identifier (DOI)

  • 10.1097/00131402-200012000-00003


  • eng

Conference Location

  • United States