A photo-caged platinum(II) complex that increases cytotoxicity upon light activation
Journal Article (Journal Article)
A novel platinum(II) photocaged complex called [Pt(cage)] has been prepared and characterized by X-ray crystallography. The complex contains a photolabile nitrophenyl group incorporated into the backbone of a tetradentate ligand that contains two pyridyl and two amide nitrogen donor sites. The intact complex is unreactive toward ligand-exchange reactions until activation with UV light cleaves the ligand backbone, releasing a PtII complex that more readily exchanges its ligands, as verified by reaction with a methioninc-containing peptide. [Pt(cage)] is non-toxic to MCF-7 cells in the dark, whereas brief UV exposure induces cell death of human breast cancer MCF-7 cells at a level approaching that of cisplatin. By using light to alter the coordination chemistry around the metal center, [Pt(cage)] represents a new strategy for potentially delivering metal-based drugs in a site and time specific manner. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Full Text
Duke Authors
Cited Authors
- Ciesienski, KL; Hyman, LM; Yang, DT; Haas, KL; Dickens, MG; Holbrook, RJ; Franz, KJ
Published Date
- May 1, 2010
Published In
Start / End Page
- 2224 - 2228
Electronic International Standard Serial Number (EISSN)
- 1099-0682
International Standard Serial Number (ISSN)
- 1434-1948
Digital Object Identifier (DOI)
- 10.1002/ejic.201000098
Citation Source
- Scopus