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A photo-caged platinum(II) complex that increases cytotoxicity upon light activation

Publication ,  Journal Article
Ciesienski, KL; Hyman, LM; Yang, DT; Haas, KL; Dickens, MG; Holbrook, RJ; Franz, KJ
Published in: European Journal of Inorganic Chemistry
January 1, 2010

A novel platinum(II) photocaged complex called [Pt(cage)] has been prepared and characterized by X-ray crystallography. The complex contains a photolabile nitrophenyl group incorporated into the backbone of a tetradentate ligand that contains two pyridyl and two amide nitrogen donor sites. The intact complex is unreactive toward ligand-exchange reactions until activation with UV light cleaves the ligand backbone, releasing a PtII complex that more readily exchanges its ligands, as verified by reaction with a methioninc-containing peptide. [Pt(cage)] is non-toxic to MCF-7 cells in the dark, whereas brief UV exposure induces cell death of human breast cancer MCF-7 cells at a level approaching that of cisplatin. By using light to alter the coordination chemistry around the metal center, [Pt(cage)] represents a new strategy for potentially delivering metal-based drugs in a site and time specific manner. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Duke Scholars

Published In

European Journal of Inorganic Chemistry

DOI

EISSN

1099-0682

ISSN

1434-1948

Publication Date

January 1, 2010

Issue

15

Start / End Page

2224 / 2228

Related Subject Headings

  • Inorganic & Nuclear Chemistry
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0302 Inorganic Chemistry
 

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Ciesienski, K. L., Hyman, L. M., Yang, D. T., Haas, K. L., Dickens, M. G., Holbrook, R. J., & Franz, K. J. (2010). A photo-caged platinum(II) complex that increases cytotoxicity upon light activation. European Journal of Inorganic Chemistry, (15), 2224–2228. https://doi.org/10.1002/ejic.201000098
Ciesienski, K. L., L. M. Hyman, D. T. Yang, K. L. Haas, M. G. Dickens, R. J. Holbrook, and K. J. Franz. “A photo-caged platinum(II) complex that increases cytotoxicity upon light activation.” European Journal of Inorganic Chemistry, no. 15 (January 1, 2010): 2224–28. https://doi.org/10.1002/ejic.201000098.
Ciesienski KL, Hyman LM, Yang DT, Haas KL, Dickens MG, Holbrook RJ, et al. A photo-caged platinum(II) complex that increases cytotoxicity upon light activation. European Journal of Inorganic Chemistry. 2010 Jan 1;(15):2224–8.
Ciesienski, K. L., et al. “A photo-caged platinum(II) complex that increases cytotoxicity upon light activation.” European Journal of Inorganic Chemistry, no. 15, Jan. 2010, pp. 2224–28. Scopus, doi:10.1002/ejic.201000098.
Ciesienski KL, Hyman LM, Yang DT, Haas KL, Dickens MG, Holbrook RJ, Franz KJ. A photo-caged platinum(II) complex that increases cytotoxicity upon light activation. European Journal of Inorganic Chemistry. 2010 Jan 1;(15):2224–2228.
Journal cover image

Published In

European Journal of Inorganic Chemistry

DOI

EISSN

1099-0682

ISSN

1434-1948

Publication Date

January 1, 2010

Issue

15

Start / End Page

2224 / 2228

Related Subject Headings

  • Inorganic & Nuclear Chemistry
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0302 Inorganic Chemistry