The Multiscale Systems Immunology project: software for cell-based immunological simulation.

Journal Article (Journal Article)

BACKGROUND: Computer simulations are of increasing importance in modeling biological phenomena. Their purpose is to predict behavior and guide future experiments. The aim of this project is to model the early immune response to vaccination by an agent based immune response simulation that incorporates realistic biophysics and intracellular dynamics, and which is sufficiently flexible to accurately model the multi-scale nature and complexity of the immune system, while maintaining the high performance critical to scientific computing. RESULTS: The Multiscale Systems Immunology (MSI) simulation framework is an object-oriented, modular simulation framework written in C++ and Python. The software implements a modular design that allows for flexible configuration of components and initialization of parameters, thus allowing simulations to be run that model processes occurring over different temporal and spatial scales. CONCLUSION: MSI addresses the need for a flexible and high-performing agent based model of the immune system.

Full Text

Duke Authors

Cited Authors

  • Mitha, F; Lucas, TA; Feng, F; Kepler, TB; Chan, C

Published Date

  • April 28, 2008

Published In

Volume / Issue

  • 3 /

Start / End Page

  • 6 -

PubMed ID

  • 18442405

Pubmed Central ID

  • PMC2426691

Electronic International Standard Serial Number (EISSN)

  • 1751-0473

Digital Object Identifier (DOI)

  • 10.1186/1751-0473-3-6


  • eng

Conference Location

  • England