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Fabrication of plastic biochips

Publication ,  Journal Article
Saaem, I; Ma, KS; Alam, SM; Tian, J
Published in: Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films
July 1, 2010

A versatile surface functionalization procedure based on rf magnetron sputtering of silica was performed on poly(methylmethacrylate), polycarbonate, polypropylene, and cyclic olefin copolymers (Topas 6015). The hybrid thermoplastic surfaces were characterized by x-ray photoelectron spectrometer analysis and contact angle measurements. The authors then used these hybrid materials to perform a sandwich assay targeting an HIV-1 antibody using fluorescent detection and biotinylated peptides immobilized using the bioaffinity of biotin-neutravidin. They found a limit of detection similar to arrays on glass surfaces and believed that this plastic biochip platform may be used for the development of disposable immunosensing and diagnostic applications. © 2010 American Vacuum Society.

Duke Scholars

Published In

Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films

DOI

ISSN

0734-2101

Publication Date

July 1, 2010

Volume

28

Issue

4

Start / End Page

963 / 968

Related Subject Headings

  • Applied Physics
  • 51 Physical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Saaem, I., Ma, K. S., Alam, S. M., & Tian, J. (2010). Fabrication of plastic biochips. Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films, 28(4), 963–968. https://doi.org/10.1116/1.3432480
Saaem, I., K. S. Ma, S. M. Alam, and J. Tian. “Fabrication of plastic biochips.” Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films 28, no. 4 (July 1, 2010): 963–68. https://doi.org/10.1116/1.3432480.
Saaem I, Ma KS, Alam SM, Tian J. Fabrication of plastic biochips. Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films. 2010 Jul 1;28(4):963–8.
Saaem, I., et al. “Fabrication of plastic biochips.” Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films, vol. 28, no. 4, July 2010, pp. 963–68. Scopus, doi:10.1116/1.3432480.
Saaem I, Ma KS, Alam SM, Tian J. Fabrication of plastic biochips. Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films. 2010 Jul 1;28(4):963–968.

Published In

Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films

DOI

ISSN

0734-2101

Publication Date

July 1, 2010

Volume

28

Issue

4

Start / End Page

963 / 968

Related Subject Headings

  • Applied Physics
  • 51 Physical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences