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B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review.

Publication ,  Journal Article
Buckley, RH
Published in: J Allergy Clin Immunol
April 2010

Although bone marrow transplantation has resulted in life-saving T-cell reconstitution in infants with severe combined immunodeficiency (SCID), correction of B-cell function has been more problematic. This review examines B-cell reconstitution results presented in 19 reports from the United States and Europe on posttransplantation immune reconstitution in patients with SCID over the past 2 decades. The analysis considered whether pretransplantation conditioning regimens were used, the overall survival rate, the percentage with donor B-cell chimerism, the percentage with B-cell function, and the percentage of survivors requiring immunoglobulin replacement. The survival rates were higher at those centers that did not use pretransplantation conditioning or posttransplantation graft-versus-host disease prophylaxis. The percentage of survivors with B-cell chimerism, function, or both was higher and the percentage requiring immunoglobulin replacement was lower at those centers that used pretransplantation conditioning. However, there were substantial numbers of patients requiring immunoglobulin replacement at all centers. Thus pretransplantation conditioning does not guarantee that B-cell function will develop. Because most infants with SCID either present with serious infections or are given diagnoses as newborns, one must decide whether there is justification for using agents that compromise innate immunity and have intrinsic toxicities to gain B-cell immune reconstitution.

Duke Scholars

Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

April 2010

Volume

125

Issue

4

Start / End Page

790 / 797

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Rate
  • Stem Cell Transplantation
  • Severe Combined Immunodeficiency
  • Multicenter Studies as Topic
  • Male
  • Infant, Newborn
  • Infant
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Buckley, R. H. (2010). B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review. J Allergy Clin Immunol, 125(4), 790–797. https://doi.org/10.1016/j.jaci.2010.02.012
Buckley, Rebecca H. “B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review.J Allergy Clin Immunol 125, no. 4 (April 2010): 790–97. https://doi.org/10.1016/j.jaci.2010.02.012.
Buckley, Rebecca H. “B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review.J Allergy Clin Immunol, vol. 125, no. 4, Apr. 2010, pp. 790–97. Pubmed, doi:10.1016/j.jaci.2010.02.012.
Buckley RH. B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review. J Allergy Clin Immunol. 2010 Apr;125(4):790–797.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

April 2010

Volume

125

Issue

4

Start / End Page

790 / 797

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Rate
  • Stem Cell Transplantation
  • Severe Combined Immunodeficiency
  • Multicenter Studies as Topic
  • Male
  • Infant, Newborn
  • Infant
  • Humans