Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity
The biocompatibility of bioerodible polyanhydrides and toxicology of the polymer breakdown products were assessed. The polymer did not provoke inflammatory responses in the corneas of rabbits over a six week implantation period. The degradation products of the polymers were nonmutagenic, noncytotoxic, and had a low teratogenic potential. The in vitro growth of mammalian cells on the polymers was unaffected as measured by cell morphology and cell growth rate. The chemical reactivity of the polyanhydrides with reactive model drugs, para substituted anilines, was also examined. No reaction occurred between the polymer and the drug during the hydrolytic degradation of the matrix at 37 degree C.