Polyanhydrides for controlled release of bioactive agents.


Journal Article

This report is a review of the development of a drug delivery system based on biorodible polyanhydrides. With the water labile anhydride linkage, a wide range of matrix degradation and drug release rates can be obtained from these drug-carriers. In addition to monolithic formulations, the feasibility of an injectable system by microencapsulation is demonstrated. The possibility of enhancing the release externally by an ultrasonic source has also been explored. The polymers tested showed good tissue biocompatibility and their breakdown products showed no adverse toxicological effects. Preliminary in vivo results confirmed the efficacy of these devices.

Full Text

Cited Authors

  • Leong, KW; Kost, J; Mathiowitz, E; Langer, R

Published Date

  • September 1986

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 364 - 371

PubMed ID

  • 3778996

Pubmed Central ID

  • 3778996

Electronic International Standard Serial Number (EISSN)

  • 1878-5905

International Standard Serial Number (ISSN)

  • 0142-9612

Digital Object Identifier (DOI)

  • 10.1016/0142-9612(86)90007-4


  • eng