Stimuli-responsive hydrogel based on poly(propylene phosphate)

Journal Article

Poly(propylene phosphate) solutions were studied and found to display a sol-gel transition temperature that can be controlled by adjusting the concentrations of polymer and Ca2+ so that the therapeutic delivery cargo is liquid at room temperature but solidifies at the in vivo temperature of 37°C. The gels showed rapid gelation kinetics but instability at high shear strains. Ion exchange between buffer and gel induced a dissociation of the network with time, leading to a zero-order controlled release of plasmid DNA or lysozyme.

Full Text

Duke Authors

Cited Authors

  • Wang, J; Sun, DN; Shin-ya, Y; Leong, KW

Published Date

  • 2004

Published In

  • Macromolecules

Volume / Issue

  • 37 / 2

Start / End Page

  • 670 - 672

Digital Object Identifier (DOI)

  • 10.1021/ma035453d