Electrohydrodynamics: A facile technique to fabricate drug delivery systems.

Published

Journal Article (Review)

Electrospinning and electrospraying are facile electrohydrodynamic fabrication methods that can generate drug delivery systems (DDS) through a one-step process. The nanostructured fiber and particle morphologies produced by these techniques offer tunable release kinetics applicable to diverse biomedical applications. Coaxial electrospinning/electrospraying, a relatively new technique of fabricating core-shell fibers/particles have added to the versatility of these DDS by affording a near zero-order drug release kinetics, dampening of burst release, and applicability to a wider range of bioactive agents. Controllable electrospinning/spraying of fibers and particles and subsequent drug release from these chiefly polymeric vehicles depends on well-defined solution and process parameters. The additional drug delivery capability from electrospun fibers can further enhance the material's functionality in tissue engineering applications. This review discusses the state-of-the-art of using electrohydrodynamic technique to generate nanofiber/particles as drug delivery devices.

Full Text

Cited Authors

  • Chakraborty, S; Liao, I-C; Adler, A; Leong, KW

Published Date

  • October 2009

Published In

Volume / Issue

  • 61 / 12

Start / End Page

  • 1043 - 1054

PubMed ID

  • 19651167

Pubmed Central ID

  • 19651167

Electronic International Standard Serial Number (EISSN)

  • 1872-8294

International Standard Serial Number (ISSN)

  • 0169-409X

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2009.07.013

Language

  • eng