Chitosan nanoparticles for oral drug and gene delivery.


Journal Article (Review)

Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems.

Full Text

Cited Authors

  • Bowman, K; Leong, KW

Published Date

  • January 2006

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 117 - 128

PubMed ID

  • 17722528

Pubmed Central ID

  • 17722528

Electronic International Standard Serial Number (EISSN)

  • 1178-2013

International Standard Serial Number (ISSN)

  • 1176-9114

Digital Object Identifier (DOI)

  • 10.2147/nano.2006.1.2.117


  • eng