Polyanhydride microsphere formulation by solvent extraction.


Journal Article

A novel process based on solvent extraction was developed to produce drug-loaded polyanhydride microspheres for controlled-release applications. The technique consists of adding a chloroform solution of polyanhydride and drug into a stirred silicone oil phase containing suspended droplets of surfactant. No chemical reaction, heating, nor contact with water was required in this process. The microspheres produced were capable of releasing various dyes for prolonged periods of time.

Full Text

Cited Authors

  • Bindschaedler, C; Leong, K; Mathiowitz, E; Langer, R

Published Date

  • August 1988

Published In

Volume / Issue

  • 77 / 8

Start / End Page

  • 696 - 698

PubMed ID

  • 3210160

Pubmed Central ID

  • 3210160

Electronic International Standard Serial Number (EISSN)

  • 1520-6017

International Standard Serial Number (ISSN)

  • 0022-3549

Digital Object Identifier (DOI)

  • 10.1002/jps.2600770811


  • eng