Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses.
In the current study, we examine the mechanism of suppression of cutaneous sensitivity (CS) responses to 4-hydroxy-3-nitrophenyl acetyl succinimide ester. Intravenous administration of haptenated syngeneic spleen cells induces a state of hapten-specific tolerance involving I-J bearing suppressor T cells that function at either the induction phase or the effector phase of the CS response. The effective phase suppressor cells (Tse) are genetically restricted by both Igh and H-2 region genes. However, a third cell population is also required in he immune lymphocyte population for immune suppression. This third cell population, termed Ts3, is an I-J+, cyclophosphamide-sensitive T cell, as shown by reconstitution experiments. Further, the Tse-Ts3 interaction is restricted by genes in he H-2 and Igh gene complexes. The results are discussed with respect to the pathway of cellular interactions leading to immuno suppression.
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Related Subject Headings
- T-Lymphocytes, Regulatory
- T-Lymphocytes
- Phenylacetates
- Phenotype
- Nitrophenols
- Mice
- Immunology
- Immune Tolerance
- Hypersensitivity, Delayed
- Hybrid Cells
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- T-Lymphocytes, Regulatory
- T-Lymphocytes
- Phenylacetates
- Phenotype
- Nitrophenols
- Mice
- Immunology
- Immune Tolerance
- Hypersensitivity, Delayed
- Hybrid Cells