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Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia?

Publication ,  Journal Article
Subramaniam, M; Sugiyama, K; Coy, DH; Kong, Y; Miller, YE; Weller, PF; Wada, K; Wada, E; Sunday, ME
Published in: Am J Respir Crit Care Med
September 1, 2003

Bombesin-like peptides (BLPs) are elevated in newborns who later develop bronchopulmonary dysplasia (BPD). In baboon models, anti-BLP blocking antibodies abrogate BPD. We now demonstrate hyperplasia of both neuroendocrine cells and mast cells in lungs of baboons with BPD, compared with non-BPD controls or BLP antibody-treated BPD baboons. To determine whether BLPs are proinflammatory, bombesin was administered intratracheally to mice. Forty-eight hours later, we observed increased numbers of lung mast cells. We analyzed murine mast cells for BLP receptor gene expression, and identified mRNAs encoding bombesin receptor subtype 3 and neuromedin-B receptor (NMB-R), but not gastrin-releasing peptide receptor. Only NMB-R-null mice accumulated fewer lung mast cells after bombesin treatment. Bombesin, gastrin-releasing peptide, NMB, and a bombesin receptor subtype 3-specific ligand induced mast cell proliferation and chemotaxis in vitro. These observations support a role for multiple BLPs in promoting mast cell responses, suggesting a mechanistic link between BLPs and chronic inflammatory lung diseases.

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Published In

Am J Respir Crit Care Med

DOI

ISSN

1073-449X

Publication Date

September 1, 2003

Volume

168

Issue

5

Start / End Page

601 / 611

Location

United States

Related Subject Headings

  • Respiratory System
  • Papio
  • Neurosecretory Systems
  • Mice
  • Mast Cells
  • Lung
  • Inflammation Mediators
  • Infant, Newborn
  • In Vitro Techniques
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Subramaniam, M., Sugiyama, K., Coy, D. H., Kong, Y., Miller, Y. E., Weller, P. F., … Sunday, M. E. (2003). Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? Am J Respir Crit Care Med, 168(5), 601–611. https://doi.org/10.1164/rccm.200212-1434OC
Subramaniam, Meera, Kumiya Sugiyama, David H. Coy, Yanping Kong, York E. Miller, Peter F. Weller, Keiji Wada, Etsuko Wada, and Mary E. Sunday. “Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia?Am J Respir Crit Care Med 168, no. 5 (September 1, 2003): 601–11. https://doi.org/10.1164/rccm.200212-1434OC.
Subramaniam M, Sugiyama K, Coy DH, Kong Y, Miller YE, Weller PF, et al. Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? Am J Respir Crit Care Med. 2003 Sep 1;168(5):601–11.
Subramaniam, Meera, et al. “Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia?Am J Respir Crit Care Med, vol. 168, no. 5, Sept. 2003, pp. 601–11. Pubmed, doi:10.1164/rccm.200212-1434OC.
Subramaniam M, Sugiyama K, Coy DH, Kong Y, Miller YE, Weller PF, Wada K, Wada E, Sunday ME. Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? Am J Respir Crit Care Med. 2003 Sep 1;168(5):601–611.

Published In

Am J Respir Crit Care Med

DOI

ISSN

1073-449X

Publication Date

September 1, 2003

Volume

168

Issue

5

Start / End Page

601 / 611

Location

United States

Related Subject Headings

  • Respiratory System
  • Papio
  • Neurosecretory Systems
  • Mice
  • Mast Cells
  • Lung
  • Inflammation Mediators
  • Infant, Newborn
  • In Vitro Techniques
  • Humans