Hapten-specific T cell response to 4-hydroxy-3-nitrophenyl acetyl. X. Characterization of distinct T cell subsets mediating cutaneous sensitivity responses.

Journal Article

NP-O-Succinimide-induced cutaneous sensitivity (CS) responses can be adoptively transferred by NP-primed lymphoid cells into naive K-, I-, or D-compatible recipients. The distinct fine specificities of I- versus D-restricted T cell clones from various strains of mice suggested that presence of different idiotypic receptors on these T cell subsets. We now demonstrate that NP-O-Su immune lymphoid cells are composed of 2 T cell subsets with distinct antigen recognition patterns, as well as different Lyt 2 phenotypes. Thus, I-restricted cells respond to NP-coupled to a protein carrier but not to NP-coupled cells, whereas D-restricted clones react to NP-cells, but not to NP-protein conjugates.

Full Text

Duke Authors

Cited Authors

  • Sunday, ME; Dorf, ME

Published Date

  • August 1981

Published In

Volume / Issue

  • 127 / 2

Start / End Page

  • 766 - 768

PubMed ID

  • 6972973

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States