Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung.

Published

Journal Article

Peribronchial smooth muscle constriction causes airway stretch, an important mechanical force in developing lung. Little is known about factors influencing these spontaneously active muscle elements. We measured contractile activity of neurokinin (NK) receptors on fetal intrapulmonary smooth muscle by tracheal perfusion assay (n = 11). Injecting either capsaicin or the NK(2) receptor agonist [NLE(10)]NKA resulted in significant (P < 0.05) bronchoconstriction. A specific NK(2) receptor antagonist inhibited constriction caused by endogenous tachykinins released by capsaicin. We then examined NK(2) receptor (n = 44) and NKA (n = 23) ontogeny in human lung. NKA immunostaining was identified in peribronchial nerves in samples with gestational age >12 wk. NK(2) receptor protein was identified in peribronchial and perivascular smooth muscle. These results indicate that endogenous tachykinins released by the developing lung act via NK(2) receptors to cause smooth muscle constriction. We speculate that tachykinins could modulate lung development.

Full Text

Duke Authors

Cited Authors

  • Haley, KJ; Sunday, ME; Osathanondh, R; Du, J; Vathanaprida, C; Karpitsky, VV; Krause, JE; Lilly, CM

Published Date

  • June 2001

Published In

Volume / Issue

  • 280 / 6

Start / End Page

  • L1348 - L1358

PubMed ID

  • 11350816

Pubmed Central ID

  • 11350816

International Standard Serial Number (ISSN)

  • 1040-0605

Digital Object Identifier (DOI)

  • 10.1152/ajplung.2001.280.6.L1348

Language

  • eng

Conference Location

  • United States