Scholars@Duke publication: CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung.

CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung.

Publication , Journal Article

Shipp, MA; Tarr, GE; Chen, CY; Switzer, SN; Hersh, LB; Stein, H; Sunday, ME; Reinherz, EL

Published in: Proc Natl Acad Sci U S A

December 1, 1991

Bombesin-like peptides are essential autocrine growth factors for many small cell carcinomas (SCCas) of the lung. Herein, we demonstrate that these malignant pulmonary neuroendocrine cells express low levels of the cell surface metalloendopeptidase CD10/neutral endopeptidase 24.11 (CD10/NEP, common acute lymphoblastic leukemia antigen) and that this enzyme hydrolyzes bombesin-like peptides. The growth of bombesin-like peptide-dependent SCC as is inhibited by CD10/NEP and potentiated by CD10/NEP inhibition. The results provide evidence that CD10/NEP is involved in the regulation of tumor cell proliferation. Since SCCa of the lung occurs almost exclusively in cigarette smokers and cigarette smoke inactivates CD10/NEP, decreased cell surface CD10/NEP enzymatic activity may be causally related to the development of SCCa of the lung.

Duke Scholars

Author Mary Elizabeth Anne Sunday Pathology

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Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.88.23.10662

ISSN

0027-8424

Publication Date

December 1, 1991

Volume

Issue

Start / End Page

10662 / 10666

Location

United States

Related Subject Headings

Substrate Specificity
Receptors, Neurotransmitter
Receptors, Bombesin
Neprilysin
Molecular Sequence Data
Lung Neoplasms
Lung
Kinetics
Immunohistochemistry
Humans

Citation

APA

Chicago

ICMJE

MLA

NLM

Shipp, M. A., Tarr, G. E., Chen, C. Y., Switzer, S. N., Hersh, L. B., Stein, H., … Reinherz, E. L. (1991). CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A, 88(23), 10662–10666. https://doi.org/10.1073/pnas.88.23.10662

Shipp, M. A., G. E. Tarr, C. Y. Chen, S. N. Switzer, L. B. Hersh, H. Stein, M. E. Sunday, and E. L. Reinherz. “CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung.” Proc Natl Acad Sci U S A 88, no. 23 (December 1, 1991): 10662–66. https://doi.org/10.1073/pnas.88.23.10662.

Shipp MA, Tarr GE, Chen CY, Switzer SN, Hersh LB, Stein H, et al. CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10662–6.

Shipp, M. A., et al. “CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung.” Proc Natl Acad Sci U S A, vol. 88, no. 23, Dec. 1991, pp. 10662–66. Pubmed, doi:10.1073/pnas.88.23.10662.

Shipp MA, Tarr GE, Chen CY, Switzer SN, Hersh LB, Stein H, Sunday ME, Reinherz EL. CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10662–10666.

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.88.23.10662

ISSN

0027-8424

Publication Date

December 1, 1991

Volume

Issue

Start / End Page

10662 / 10666

Location

United States

Related Subject Headings

Substrate Specificity
Receptors, Neurotransmitter
Receptors, Bombesin
Neprilysin
Molecular Sequence Data
Lung Neoplasms
Lung
Kinetics
Immunohistochemistry
Humans