Bombesin-like peptide and receptors in lung injury models: diverse gene expression, similar function.

Journal Article

We previously demonstrated that bombesin-like peptide (BLP) mediates lung injury in premature infants with bronchopulmonary dysplasia (BPD). We now investigate gene expression and function of BLP (gastrin-releasing peptide, GRP) and BLP-receptors (GRP-R and BRS-3) in lung from two baboon BPD models. In the "interrupted gestation model," only GRP mRNA was up-regulated. In the "hyperoxic model," GRP-R mRNA was up-regulated. In lung explants from O2-treated animals, all BPD animals responded to 1nM bombesin, whereas non-BPD animals did not; the opposite effect was observed with a BLP blocking antibody. Cumulatively, these observations suggest that novel BLPs and/or BLP receptors are likely to be implicated in the pathogenesis of BPD.

Full Text

Duke Authors

Cited Authors

  • Cullen, A; Emanuel, RL; Torday, JS; Asokananthan, N; Sikorski, KA; Sunday, ME

Published Date

  • November 2000

Published In

Volume / Issue

  • 21 / 11

Start / End Page

  • 1627 - 1638

PubMed ID

  • 11090916

International Standard Serial Number (ISSN)

  • 0196-9781

Language

  • eng

Conference Location

  • United States