Rapid noninvasive optical imaging of tissue composition in breast tumor margins.

Journal Article (Clinical Trial;Journal Article)

BACKGROUND: In women undergoing breast conserving surgery (BCS), up to 60% can require re-excision. Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors. METHODS: A prospective study of optical imaging of BCS margins is being performed. Optical images are transformed into tissue composition maps with parameters of total hemoglobin concentration, b-carotene concentration and scattering. The predicted outcome is then compared to the margin-level pathology. RESULTS: Fifty-five margins from 48 patients have undergone assessment. Within 34 specimens with pathologically confirmed positive margins, the ratio map of b-carotene/scattering showed the most significant difference reflecting a decrease in adipose and an increase in cell density within malignant margins (p=.002). These differences were notable in both in-situ and invasive disease. CONCLUSIONS: We present a novel optical spectral imaging device that provides a rapid, non-destructive assay of the tissue composition of breast tumor margins.

Full Text

Duke Authors

Cited Authors

  • Wilke, LG; Brown, JQ; Bydlon, TM; Kennedy, SA; Richards, LM; Junker, MK; Gallagher, J; Barry, WT; Geradts, J; Ramanujam, N

Published Date

  • October 2009

Published In

Volume / Issue

  • 198 / 4

Start / End Page

  • 566 - 574

PubMed ID

  • 19800470

Pubmed Central ID

  • PMC2764289

Electronic International Standard Serial Number (EISSN)

  • 1879-1883

Digital Object Identifier (DOI)

  • 10.1016/j.amjsurg.2009.06.018


  • eng

Conference Location

  • United States