Multicenter studies of tigecycline disk diffusion susceptibility results for Acinetobacter spp.

Journal Article (Journal Article;Multicenter Study)

Acinetobacter sp. isolates having multidrug resistance (MDR) patterns have become common in many medical centers worldwide, limiting therapeutic options. A five-center study tested 103 contemporary clinical Acinetobacter spp., including MDR strains, by reference broth microdilution and disk diffusion (15-mug disk content) methods against tigecycline. Applying U.S. Food and Drug Administration tigecycline breakpoint criteria for Enterobacteriaceae (susceptibility at < or =2 microg/ml [< or =1 microg/ml by the European Committee on Antimicrobial Susceptibility Testing]; disk diffusion breakpoints at > or =19 mm and < or =14 mm) to Acinetobacter spp. led to an unacceptable error rate (23.3%). However, an adjustment of tigecycline disk diffusion breakpoints (susceptible/resistant) to > or =16/ < or =12 mm reduced intermethod errors to an acceptable level (only 9.7%, all minor).

Full Text

Duke Authors

Cited Authors

  • Jones, RN; Ferraro, MJ; Reller, LB; Schreckenberger, PC; Swenson, JM; Sader, HS

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 45 / 1

Start / End Page

  • 227 - 230

PubMed ID

  • 17093026

Pubmed Central ID

  • PMC1828968

International Standard Serial Number (ISSN)

  • 0095-1137

Digital Object Identifier (DOI)

  • 10.1128/JCM.01588-06


  • eng

Conference Location

  • United States