Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective.
Journal Article (Journal Article;Multicenter Study)
Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis-Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.
Full Text
Duke Authors
- Chu, Vivian Hou
- Federspiel, Jerome Jeffrey
- Fowler Jr., Vance Garrison
- Reller, Lyman Barth
- Woods, Christopher Wildrick
Cited Authors
- Petti, CA; Simmon, KE; Miro, JM; Hoen, B; Marco, F; Chu, VH; Athan, E; Bukovski, S; Bouza, E; Bradley, S; Fowler, VG; Giannitsioti, E; Gordon, D; Reinbott, P; Korman, T; Lang, S; Garcia-de-la-Maria, C; Raglio, A; Morris, AJ; Plesiat, P; Ryan, S; Doco-Lecompte, T; Tripodi, F; Utili, R; Wray, D; Federspiel, JJ; Boisson, K; Reller, LB; Murdoch, DR; Woods, CW; International Collaboration on Endocarditis-Microbiology Investigators,
Published Date
- May 2008
Published In
Volume / Issue
- 46 / 5
Start / End Page
- 1780 - 1784
PubMed ID
- 18367572
Pubmed Central ID
- PMC2395089
Electronic International Standard Serial Number (EISSN)
- 1098-660X
Digital Object Identifier (DOI)
- 10.1128/JCM.02405-07
Language
- eng
Conference Location
- United States