Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective.

Journal Article (Journal Article;Multicenter Study)

Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis-Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.

Full Text

Duke Authors

Cited Authors

  • Petti, CA; Simmon, KE; Miro, JM; Hoen, B; Marco, F; Chu, VH; Athan, E; Bukovski, S; Bouza, E; Bradley, S; Fowler, VG; Giannitsioti, E; Gordon, D; Reinbott, P; Korman, T; Lang, S; Garcia-de-la-Maria, C; Raglio, A; Morris, AJ; Plesiat, P; Ryan, S; Doco-Lecompte, T; Tripodi, F; Utili, R; Wray, D; Federspiel, JJ; Boisson, K; Reller, LB; Murdoch, DR; Woods, CW; International Collaboration on Endocarditis-Microbiology Investigators,

Published Date

  • May 2008

Published In

Volume / Issue

  • 46 / 5

Start / End Page

  • 1780 - 1784

PubMed ID

  • 18367572

Pubmed Central ID

  • PMC2395089

Electronic International Standard Serial Number (EISSN)

  • 1098-660X

Digital Object Identifier (DOI)

  • 10.1128/JCM.02405-07


  • eng

Conference Location

  • United States