Correlation of cefoxitin MICs with the presence of mecA in Staphylococcus spp.

Journal Article (Journal Article;Multicenter Study)

This report describes the results of an 11-laboratory study to determine if a cefoxitin broth microdilution MIC test could predict the presence of mecA in staphylococci. Using breakpoints of < or = 4 microg/ml for mecA-negative and > or = 6 or 8 microg/ml for mecA-positive isolates, sensitivity and specificity based on mecA or presumed mecA for Staphylococcus aureus at 18 h of incubation were 99.7 to 100% in three cation-adjusted Mueller-Hinton broths tested. For coagulase-negative strains at 24 h of incubation, breakpoints of < or = 2 microg/ml for mecA-negative and > or = 4 microg/ml for mecA-positive isolates gave sensitivity and specificity of 94 to 99% and 69 to 80%, respectively.

Full Text

Duke Authors

Cited Authors

  • Swenson, JM; Brasso, WB; Ferraro, MJ; Hardy, DJ; Knapp, CC; Lonsway, D; McAllister, S; Reller, LB; Sader, HS; Shortridge, D; Skov, R; Weinstein, MP; Zimmer, BL; Patel, JB

Published Date

  • June 2009

Published In

Volume / Issue

  • 47 / 6

Start / End Page

  • 1902 - 1905

PubMed ID

  • 19357210

Pubmed Central ID

  • PMC2691132

Electronic International Standard Serial Number (EISSN)

  • 1098-660X

Digital Object Identifier (DOI)

  • 10.1128/JCM.02304-08


  • eng

Conference Location

  • United States