IDH1 and IDH2: not your typical oncogenes.

Journal Article (Journal Article)

Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.

Full Text

Duke Authors

Cited Authors

  • Reitman, ZJ; Parsons, DW; Yan, H

Published Date

  • March 16, 2010

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 215 - 216

PubMed ID

  • 20227034

Pubmed Central ID

  • PMC4467912

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2010.02.024


  • eng

Conference Location

  • United States