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Novel targets for immunotherapy in glomerulonephritis.

Publication ,  Journal Article
Foster, MH
Published in: Biologics
September 2008

Glomerulonephritis is a common cause of chronic kidney disease and end stage renal failure. Current therapy relies on variably effective, nonspecific and toxic immunosuppression. Recent insights into underlying biology and disease pathogenesis in human glomerulonephritis combined with advances in the fields of inflammation and autoimmunity promise a cadre of novel targeted interventions. This review highlights the therapeutic potential of two antigens, alpha3 (IV)NC1 collagen and podocyte neutral endopeptidase, and two cell signaling and effector molecules, IgG Fc receptors and complement, judged to be particularly amenable to therapeutic manipulation in man. It is anticipated that continued dissection of pathogenesis in the diverse disorders that comprise the glomerulonephritides will provide the basis for individualized disease-specific therapy.

Duke Scholars

Published In

Biologics

DOI

ISSN

1177-5475

Publication Date

September 2008

Volume

2

Issue

3

Start / End Page

531 / 545

Location

New Zealand

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3202 Clinical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Foster, M. H. (2008). Novel targets for immunotherapy in glomerulonephritis. Biologics, 2(3), 531–545. https://doi.org/10.2147/btt.s2764
Foster, Mary H. “Novel targets for immunotherapy in glomerulonephritis.Biologics 2, no. 3 (September 2008): 531–45. https://doi.org/10.2147/btt.s2764.
Foster MH. Novel targets for immunotherapy in glomerulonephritis. Biologics. 2008 Sep;2(3):531–45.
Foster, Mary H. “Novel targets for immunotherapy in glomerulonephritis.Biologics, vol. 2, no. 3, Sept. 2008, pp. 531–45. Pubmed, doi:10.2147/btt.s2764.
Foster MH. Novel targets for immunotherapy in glomerulonephritis. Biologics. 2008 Sep;2(3):531–545.

Published In

Biologics

DOI

ISSN

1177-5475

Publication Date

September 2008

Volume

2

Issue

3

Start / End Page

531 / 545

Location

New Zealand

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3202 Clinical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences