Does IVIg administration yield improved immune function in very premature neonates?

Published

Journal Article (Review)

Intravenous immunoglobulin (IVIg) has been evaluated as an adjunctive therapy for neonatal sepsis with modest clinical success despite strong biological plausibility. Multiple factors contribute to this outcome, but perhaps none greater than the limited immune system function in newborns, especially in the very premature neonates. For very premature neonates (<30 weeks gestational age), understanding the effects of IVIg on specific immature immune system functions is particularly relevant given their preponderance to develop sepsis and therefore potentially benefit from IVIg-mediated immunoenhancement. Here, we review the available evidence for enhanced immune function after IVIg administration in very premature neonates and highlight areas for future research.

Full Text

Duke Authors

Cited Authors

  • Wynn, JL; Seed, PC; Cotten, CM

Published Date

  • October 2010

Published In

Volume / Issue

  • 30 / 10

Start / End Page

  • 635 - 642

PubMed ID

  • 20054335

Pubmed Central ID

  • 20054335

Electronic International Standard Serial Number (EISSN)

  • 1476-5543

International Standard Serial Number (ISSN)

  • 0743-8346

Digital Object Identifier (DOI)

  • 10.1038/jp.2009.197

Language

  • eng