Genetic variation among strains of wild-type yellow fever virus from Senegal.

Published

Journal Article

We have examined and compared at the molecular level three strains of wild-type yellow fever (YF) virus isolated from Senegal in 1927, 1953 and 1965, termed French viscerotropic virus, Rendu and Dak1279 respectively. Over the structural protein genes, Rendu differed from the other two strains by 8% at the nucleotide level. Rendu also differed antigenically, possessing a 'vaccine'-specific envelope (E) protein epitope (i.e. an epitope previously shown to be found on 17D and French neurotropic vaccine viruses only and not wild-type strains of YF virus). Consequently, we propose that at least two distinct genotypes of wild-type YF virus have been present in Senegal. Since Rendu virus was isolated from a fatal case of YF, it would indicate that the vaccine-specific epitope on the E protein is not associated with attenuation of the viscerotropism of wild-type YF virus.

Full Text

Duke Authors

Cited Authors

  • Wang, H; Jennings, AD; Ryman, KD; Late, CM; Wang, E; Ni, H; Minor, PD; Barrett, AD

Published Date

  • June 1997

Published In

Volume / Issue

  • 78 ( Pt 6) /

Start / End Page

  • 1349 - 1352

PubMed ID

  • 9191928

Pubmed Central ID

  • 9191928

International Standard Serial Number (ISSN)

  • 0022-1317

Digital Object Identifier (DOI)

  • 10.1099/0022-1317-78-6-1349

Language

  • eng

Conference Location

  • England