Expression of HSP70 in peripheral lymphocytes of the patients with allergic rhinitis.


Journal Article

The expression levels of heat shock protein 70 (HSP70) from peripheral lymphocytes of the patients with allergic rhinitis (AR) and the clinical implication were investigated. In the morning, 3 ml of fasting venous blood was taken out. The lymphocytes were isolated by using Ficoll-Hypaque and the expression of HSP70 in the lymphocytes was detected by using Western blot. In the AR patients the HSP70 level (41.49 +/- 15.77 integrated optical density, IOD) were significantly higher than that in the control group (23.89 +/- 10.13 IOD, P < 0.05). Western blot demonstrated that HSP70 bands in AR patients were more intensive than those in the control group. It was concluded that the elevated HSP70 level in peripheral lymphocytes of the AR patients might contribute to the development of AR.

Full Text

Duke Authors

Cited Authors

  • Liu, L; Xiao, C; Zhang, M; Cheng, L; Wang, E; Wu, T

Published Date

  • 2003

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 310 - 312

PubMed ID

  • 14526444

Pubmed Central ID

  • 14526444

International Standard Serial Number (ISSN)

  • 1672-0733


  • eng

Conference Location

  • China