Cancer systems biology: exploring cancer-associated genes on cellular networks.

Journal Article (Review)

Genomic alterations lead to cancer complexity and form a major hurdle for comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe recent advances in studying cancer-associated genes from a systems biology point of view. The integration of known cancer genes onto protein and signaling networks reveals the characteristics of cancer genes within networks. This approach shows that cancer genes often function as network hub proteins which are involved in many cellular processes and form focal nodes in information exchange between many signaling pathways. Literature mining allows constructing gene-gene networks, in which new cancer genes can be identified. The gene expression profiles of cancer cells are used for reconstructing gene regulatory networks. By doing so, genes which are involved in the regulation of cancer progression can be picked up from these networks, after which their functions can be further confirmed in the laboratory.

Full Text

Duke Authors

Cited Authors

  • Wang, E; Lenferink, A; O'Connor-McCourt, M

Published Date

  • July 2007

Published In

Volume / Issue

  • 64 / 14

Start / End Page

  • 1752 - 1762

PubMed ID

  • 17415519

International Standard Serial Number (ISSN)

  • 1420-682X

Digital Object Identifier (DOI)

  • 10.1007/s00018-007-7054-6

Language

  • eng

Conference Location

  • Switzerland