Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice.
Journal Article (Journal Article)
The acute and accumulated toxicity of the rare earth borotungstate heteropoly blues, HPB-2, Ce2H3[BW9(VI)W2(V)Mn(H2O)O39].12H2O, which is active against influenza virus in Kunming mice, were investigated in Kunming mice following oral and intraperitoneal administration. The activity of HPB-2 against influenza virus (FM1) in the mice was then investigated. HPB-2, given either orally (p.o.) or intraperitoneally (i.p.), was shown to have activity. HPB-2 was shown to be more effective than the positive control, ribavirin, and it was also found that i.p. administration was more effective than p.o. administration.
Full Text
Duke Authors
Cited Authors
- Liu, J; Mei, W; Li, Y; Wang, E; Ji, L; Tao, P
Published Date
- November 2000
Published In
Volume / Issue
- 11 / 6
Start / End Page
- 367 - 372
PubMed ID
- 11227994
International Standard Serial Number (ISSN)
- 0956-3202
Digital Object Identifier (DOI)
- 10.1177/095632020001100603
Language
- eng
Conference Location
- England