Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice.

Journal Article (Journal Article)

The acute and accumulated toxicity of the rare earth borotungstate heteropoly blues, HPB-2, Ce2H3[BW9(VI)W2(V)Mn(H2O)O39].12H2O, which is active against influenza virus in Kunming mice, were investigated in Kunming mice following oral and intraperitoneal administration. The activity of HPB-2 against influenza virus (FM1) in the mice was then investigated. HPB-2, given either orally (p.o.) or intraperitoneally (i.p.), was shown to have activity. HPB-2 was shown to be more effective than the positive control, ribavirin, and it was also found that i.p. administration was more effective than p.o. administration.

Full Text

Duke Authors

Cited Authors

  • Liu, J; Mei, W; Li, Y; Wang, E; Ji, L; Tao, P

Published Date

  • November 2000

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 367 - 372

PubMed ID

  • 11227994

International Standard Serial Number (ISSN)

  • 0956-3202

Digital Object Identifier (DOI)

  • 10.1177/095632020001100603


  • eng

Conference Location

  • England