MicroRNAs preferentially target the genes with high transcriptional regulation complexity.

Journal Article

Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal genomes at post-transcriptional level. However, it is still unclear why some genes are regulated by miRNAs but others are not, i.e. what principles govern miRNA regulation in animal genomes. In this study, we systematically analyzed the relationship between transcription factors (TFs) and miRNAs in gene regulation. We found that the genes with more TF-binding sites have a higher probability of being targeted by miRNAs and have more miRNA-binding sites on average. This observation reveals that the genes with higher cis-regulation complexity are more coordinately regulated by TFs at the transcriptional level and by miRNAs at the post-transcriptional level. This is a potentially novel discovery of mechanism for coordinated regulation of gene expression. Gene ontology analysis further demonstrated that such coordinated regulation is more popular in the developmental genes.

Full Text

Duke Authors

Cited Authors

  • Cui, Q; Yu, Z; Pan, Y; Purisima, EO; Wang, E

Published Date

  • January 19, 2007

Published In

Volume / Issue

  • 352 / 3

Start / End Page

  • 733 - 738

PubMed ID

  • 17141185

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2006.11.080

Language

  • eng

Conference Location

  • United States